A Practical Synthesis of N-Acetyl-5-methoxy-tryptamine (Melatonin)
- 1 June 1999
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 29 (12), 2099-2104
- https://doi.org/10.1080/00397919908086203
Abstract
The pineal hormone melatonin is conveniently prepared in a simple one pot operation by treating 4-methoxyphenylhydrazine hydrochloride(6) with acetic anhydride and 4-aminobutyraldehyde dimethylacetal(4) in a mixed solvent system of acetic acid / ethanol / water.Keywords
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