Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
Open Access
- 19 June 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 123 (25), 3988-3998
- https://doi.org/10.1182/blood-2014-03-562231
Abstract
Key Points T follicular helper cells and germinal center B cells are increased and strongly correlate with the development of cGVHD in a murine model. Blocking mAbs for IL-21, ICOS, and CD40L are potential novel therapeutics for cGVHD.Keywords
This publication has 35 references indexed in Scilit:
- Increased BCR responsiveness in B cells from patients with chronic GVHDBlood, 2014
- Human circulating influenza-CD4 + ICOS1 + IL-21 + T cells expand after vaccination, exert helper function, and predict antibody responsesProceedings of the National Academy of Sciences of the United States of America, 2013
- Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cellsCurrent Opinion in Immunology, 2013
- The development and fate of follicular helper T cells defined by an IL-21 reporter mouseNature Immunology, 2012
- Germinal Center Alloantibody Responses Are Mediated Exclusively by Indirect-Pathway CD4 T Follicular Helper CellsThe Journal of Immunology, 2012
- IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generationBlood, 2009
- Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host diseaseBlood, 2009
- ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunityThe Journal of Experimental Medicine, 2008
- Chronic graft-versus-host disease following umbilical cord blood transplantation: retrospective survey involving 1072 patients in JapanBlood, 2008
- ICOS, CD40, and Lymphotoxin β Receptors Signal Sequentially and Interdependently to Initiate a Germinal Center ReactionThe Journal of Immunology, 2008