Fetal regulation of iron transport during pregnancy
Open Access
- 1 December 2011
- journal article
- review article
- Published by Oxford University Press (OUP) in The American Journal of Clinical Nutrition
- Vol. 94 (6 Suppl), S1903-S1907
- https://doi.org/10.3945/ajcn.110.000885
Abstract
During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. In this article, we examine how iron is transferred from the maternal liver to the placenta, taken up, and transferred to the fetal liver. We consider the molecular mechanisms and how they are regulated. In addition, we use data from previously published articles to examine how the processes are regulated and what adaptations can occur to ameliorate the consequences of iron deficiency—an all too common problem in pregnancy, even in the developed world. Finally, we examine some of the many questions that remain about the transfer process and consider how nutrients interact and what the consequences of these interactions may be for the mother and her developing infant.Keywords
This publication has 31 references indexed in Scilit:
- Identification of Zyklopen, a New Member of the Vertebrate Multicopper Ferroxidase Family, and Characterization in Rodents and Human CellsJournal of Nutrition, 2010
- The relationship between dietary supplement use in late pregnancy and birth outcomes: a cohort study in British womenBJOG: An International Journal of Obstetrics and Gynaecology, 2010
- Application of the Dietary Reference Intakes in developing a recommendation for pregnancy iron supplements in CanadaThe American Journal of Clinical Nutrition, 2009
- Provision of Multiple Rather Than Two or Fewer Micronutrients More Effectively Improves Growth and Other Outcomes in Micronutrient-Deficient Children and AdultsJournal of Nutrition, 2009
- Iron supplement in pregnancy and development of gestational diabetes—a randomised placebo‐controlled trialBJOG: An International Journal of Obstetrics and Gynaecology, 2009
- Iron metabolism in the anemia of chronic diseaseBiochimica et Biophysica Acta (BBA) - General Subjects, 2008
- The role of iron regulatory proteins in mammalian iron homeostasis and diseaseNature Chemical Biology, 2006
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its InternalizationScience, 2004
- Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the ratGut, 2004
- Iron deficiency during pregnancy affects postnatal blood pressure in the ratThe Journal of Physiology, 2003