Overview and report on international registry of sarcoid arthritis in childhood
- 1 August 2000
- journal article
- research article
- Published by Springer Science and Business Media LLC in Current Rheumatology Reports
- Vol. 2 (4), 343-348
- https://doi.org/10.1007/s11926-000-0073-z
Abstract
Interest in childhood sarcoidosis prompted the formation of an international registry in 1991. Over the next 5 years, 53 patients were registered by 23 physicians from 14 countries. All the patients had definite histologic evidence of sarcoidosis: noncaseating granulomas of the skin (31), synovium (15), liver (10), lymph node (eight), lung (five), muscle (four), conjunctiva (three), or kidney (one). All but nine patients developed polyarthritis; 38 of 44 had persistent arthritis. Of those with persistent polyarthritis, arthritis occurred at presentation in 16 of 38 patients and inflammation of the uveal tract of the eye occurred in 44 with involvement of both anterior and posterior segments in 21. One patient was blind at the time of the report. Other ocular complications included chorioretinitis, glaucoma, and phthisis bulbi. Laboratory abnormalities included mild anemia and elevated erythrocyte sedimentation rate (39 out of 45). Angiotensin converting enzyme levels were elevated in 14 out of 37 patients. Information on these patients with sarcoidosis helps develop a better understanding of this rare childhood disease. These patients are discussed in conjunction with an overview of sarcoid arthropathy.Keywords
This publication has 44 references indexed in Scilit:
- Low-dose methotrexate therapy for childhood sarcoidosisThe Journal of Pediatrics, 1997
- Childhood sarcoidosisThe Journal of Pediatrics, 1986
- FAMILIAL GRANULOMATOUS ARTHRITIS, IRITIS, AND RASHThe Journal of Pediatrics, 1984
- Central Nervous System Manifestations of Sarcoidosis in ChildrenClinical Pediatrics, 1983
- Pulmonary SarcoidosisThe New England Journal of Medicine, 1981
- Serum angiotensin-converting enzyme activity in normal children and in those with sarcoidosisThe Journal of Pediatrics, 1981
- Chloroquine in the treatment of sarcoidosis: A report from the Research Committee of the Bristish Tuberculosis AssociationTubercle, 1967
- Sarcoidosis with polyarthritis in a child.Archives of Disease in Childhood, 1967
- Rare diagnosis: sarcoid arthritis in four childrenJAMA, 1966
- A CASE OF BOECK'S SARCOIDOSISBritish Journal of Ophthalmology, 1941