Polypeptide Synthesis in Mumps Virus-infected Cells

Abstract

Summary The synthesis of polypeptides in infected Vero cells has been studied with two tissue culture adapted strains of mumps virus. Minor differences between the strains are found in the mobilities of the virus-specific polypeptides in SDS-PAGE. Eight virus-induced polypeptides have been identified with mol. wt. of 180K, 80K, 71K, 69K, 45K, 39K, 23K and 17K. These may correspond to the L, HN, N, F0, P, M, C and S polypeptides identified in other paramyxoviruses. The 69K F0 glycoprotein is probably a precursor for glycopolypeptides F1 and F2 with mol. wt. 61K and 14K, respectively.