Prognostic Subgroups in B-Cell Chronic Lymphocytic Leukemia Defined by Specific Chromosomal Abnormalities
- 13 September 1990
- journal article
- research article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 323 (11), 720-724
- https://doi.org/10.1056/nejm199009133231105
Abstract
Specific chromosomal abnormalities have been shown to affect the overall survival of patients with acute leukemia, but the possibility that specific chromosomal defects may influence the course of B-cell chronic lymphocytic leukemia (CLL) is controversial. We assessed this possibility as follows: blood mononuclear cells from 433 patients with B-cell CLL in five European centers were cultured with B-cell mitogens, and banded metaphases were studied.Keywords
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