Quantitative proteomics and biomarker discovery in human cancer
- 1 April 2009
- journal article
- Published by Informa UK Limited in Expert Review of Proteomics
- Vol. 6 (2), 115-118
- https://doi.org/10.1586/epr.09.8
Abstract
“Early diagnosis and prevention is a key factor in reducing the mortality and morbidity of cancer. However, currently available screening tools lack enough sensitivity for early diagnosis. It is important to develop noninvasive techniques and methods that can screen and identify asymptomatic patients who have cancer. Biomarkers of cancer status can also serve as powerful tools in monitoring the course of cancer, and in determining the efficacy and safety of novel therapies. Thus, discovery of novel specific biomarkers are needed that may provide informative clues for early diagnosis and treatment of cancer. Recently, remarkable progress has been made in the development of new proteomics technology. The progress that has been made in this field is helpful in identifying biomarkers that can be used for early diagnosis of cancer and improving the understanding of the molecular etiological mechanism of cancer. This article describes the current state of the art in this field.”Keywords
This publication has 37 references indexed in Scilit:
- Insights from site-specific phosphoproteomics in bacteriaBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2008
- The Absolute Quantification StrategyPublished by Springer Science and Business Media LLC ,2007
- Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK)Nature Methods, 2006
- Protein biomarker discovery and validation: the long and uncertain path to clinical utilityNature Biotechnology, 2006
- Shotgun proteomics using the iTRAQ isobaric tagsBriefings in Functional Genomics and Proteomics, 2006
- Biomarker Discovery from Pancreatic Cancer Secretome Using a Differential Proteomic ApproachMolecular & Cellular Proteomics, 2006
- The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modificationsMethods, 2005
- Proteome dynamics in complex organisms: Using stable isotopes to monitor individual protein turnover ratesProteomics, 2005
- Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritisArthritis & Rheumatism, 2004
- Molecular Biologist's Guide to ProteomicsMicrobiology and Molecular Biology Reviews, 2002