Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
- 1 October 1986
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 323 (6087), 411-416
- https://doi.org/10.1038/323411a0
Abstract
Cloning and sequence analysis of DNA complementary to porcine cerebral messenger RNA encoding the muscarinic acetylcholine receptor predict the complete amino-acid sequence of this protein. Expression of the complementary DNA produces functional muscarinic receptor in Xenopus oocytes. The muscarinic receptor is homologous with the β-adrenergic receptor and rhodopsin in both amino-acid sequence and suggested transmembrane topography.Keywords
This publication has 51 references indexed in Scilit:
- Neuropharmacology: Acetylcholine and brain cellsNature, 1986
- Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory proteinNature, 1985
- 1984 at the BarbicanTrends in Pharmacological Sciences, 1984
- G proteins and dual control of adenylate cyclaseCell, 1984
- Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAsNucleic Acids Research, 1984
- Muscarinic receptor subclassesTrends in Pharmacological Sciences, 1983
- High-efficiency cloning of full-length cDNA.Molecular and Cellular Biology, 1982
- Codon catalog usage is a genome strategy modulated for gene expressivityNucleic Acids Research, 1981
- [57] Sequencing end-labeled DNA with base-specific chemical cleavagesMethods in enzymology, 1980
- Pirenzepine distinguishes between different subclasses of muscarinic receptorsNature, 1980