Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii
- 18 October 2006
- journal article
- research article
- Published by Elsevier BV in Tetrahedron Letters
- Vol. 47 (48), 8625-8628
- https://doi.org/10.1016/j.tetlet.2006.08.113
Abstract
Zygosporamide (1), a new cyclic pentadepsipeptide, was isolated from the seawater-based fermentation broth of a marine-derived fungus identified as Zygosporium masonii. The structure of 1, which is composed of α-hydroxyleucic acid and both d- and l-amino acids, was determined by combined spectral and chemical methods. Despite a simple structure, zygosporamide illustrated significant cytotoxicity in the NCI’s 60 cell line panel (median GI50 = 9.1 μM), with highly enhanced selectivity against the CNS cancer cell line SF-268 (GI50 = 6.5 nM) and the renal cancer cell line RXF 393 (GI50 ⩽ 5.0 nM).Keywords
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