Review of Ets1 structure, function, and roles in immunity
- 5 January 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 70 (18), 3375-3390
- https://doi.org/10.1007/s00018-012-1243-7
Abstract
The Ets1 transcription factor is a member of the Ets gene family and is highly conserved throughout evolution. Ets1 is known to regulate a number of important biological processes in normal cells and in tumors. In particular, Ets1 has been associated with regulation of immune cell function and with an aggressive behavior in tumors that express it at high levels. Here we review and summarize the general features of Ets1 and describe its roles in immunity and autoimmunity, with a focus on its roles in B lymphocytes. We also review evidence that suggests that Ets1 may play a role in malignant transformation of hematopoietic malignancies including B cell malignancies.Keywords
This publication has 173 references indexed in Scilit:
- Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populationsEuropean Journal of Human Genetics, 2012
- Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunityNature Genetics, 2012
- Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac diseaseNature Genetics, 2011
- Analysis of the coding genome of diffuse large B-cell lymphomaNature Genetics, 2011
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaNature, 2011
- Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cellsJournal of Molecular Medicine, 2010
- Multiple common variants for celiac disease influencing immune gene expressionNature Genetics, 2010
- Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5Journal of Molecular Biology, 2009
- The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoansNature, 2008
- PIASy controls ubiquitination-dependent proteasomal degradation of Ets-1Biochemical Journal, 2007