High prevalence of restless legs syndrome in multiple sclerosis
- 11 April 2007
- journal article
- Published by Wiley in European Journal of Neurology
- Vol. 14 (5), 534-539
- https://doi.org/10.1111/j.1468-1331.2007.01740.x
Abstract
Despite the fact that multiple sclerosis (MS) patients often include leg restlessness as a sensory symptom, MS is not mentioned amongst symptomatic restless legs syndrome (RLS) forms. The aim of this study was to estimate RLS prevalence in a large population of MS patients, comparing clinical and MRI findings between patients with and without RLS. Each of the 156 MS patients (100 females, 56 males, mean age 40.7 ± 10.4) enrolled in a prospective study underwent a medical history interview, a neurological examination with the assessment of the Expanded Disability Status Scale (EDSS), and a structured questionnaire to verify the presence and features of RLS. Conventional brain–spinal MRIs of 99 subjects were also evaluated and compared between patients with and without RLS. Fifty‐one subjects (32.7%) (mean age 43.8 ± 12.8) met the criteria for RLS. In a few patients (8.5%), the RLS preceded clinical MS onset, whilst in the remaining cases the RLS was followed by or was simultaneous with clinical MS onset. Comparing the RLS group with the group without RLS, no significant differences were found in MS duration, gender, and referred sleep habits. The primary progressive MS course was more represented in the RLS group, which also showed a higher EDSS score. RLS is a very common finding in MS patients and should be considered amongst the symptomatic RLS forms. RLS is also associated with higher disability.Keywords
This publication has 32 references indexed in Scilit:
- Final Height in Children with Medulloblastoma Treated with Growth HormoneHormone Research in Paediatrics, 2005
- The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterizationClinical Neurophysiology, 2004
- Epidemiology and clinical findings of restless legs syndromeSleep Medicine, 2004
- Parkinson's disease and RLS: the dopaminergic bridgeSleep Medicine, 2004
- Genomewide Linkage Scan Identifies a Novel Susceptibility Locus for Restless Legs Syndrome on Chromosome 9pAmerican Journal of Human Genetics, 2004
- Iron, RLS and blood donationsSleep Medicine, 2004
- Restless legs syndrome: diagnostic criteria, special considerations, and epidemiologySleep Medicine, 2003
- Sensory symptoms of multiple sclerosis: a hidden reservoir of morbidityMultiple Sclerosis Journal, 1999
- A CLINICAL, SEROLOGICAL AND NEUROPHYSIOLOGICAL STUDY OF RESTLESS LEGS SYNDROME IN RHEUMATOID ARTHRITISRheumatology, 1994
- Rating neurologic impairment in multiple sclerosisNeurology, 1983