Alterations in Brain Norepinephrine Metabolism Induced by Environmental Stimuli Previously Paired with Inescapable Shock
- 5 September 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 209 (4461), 1138-1140
- https://doi.org/10.1126/science.7403874
Abstract
Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO4), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.Keywords
This publication has 23 references indexed in Scilit:
- Stress and Coping Factors Influence Tumor GrowthScience, 1979
- ON THE ORIGIN OF VANILLYLMANDELIC ACID AND 3‐METHOXY‐4‐HYDROXY‐PHENYLGLYCOL IN THE RAT BRAINJournal of Neurochemistry, 1978
- Environmental events that modify the catecholamine fluorescence of the A2 cell bodies in nucleus tractus solitarii.Journal of Comparative and Physiological Psychology, 1978
- Cholinergic Changes During Conditioned Suppression in RatsScience, 1976
- Release of 14C-norepinephrine into the lateral cerebroventricle of rats by exposure to a conditioned aversive stimulusPharmacology Biochemistry and Behavior, 1975
- Effect of stress on sulfated glycol metabolites of brain norepinephrineLife Sciences, 1975
- The effects of restraint and noncontingent preshock on subsequent escape learning in the ratLearning and Motivation, 1974
- ADRENOCORTICAL FUNCTION AND THE MEASUREMENT OF “EMOTIONALITY”*Annals of the New York Academy of Sciences, 1969
- Effects of limbic lesions on passive avoidance and reactivity to shock.Journal of Comparative and Physiological Psychology, 1968
- Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.Journal of Comparative Psychology, 1934