CT Perfusion Identifies Increased Salvage of Tissue in Patients Receiving Intravenous Recombinant Tissue Plasminogen Activator within 3 Hours of Stroke Onset
Open Access
- 10 April 2008
- journal article
- research article
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 29 (6), 1118-1123
- https://doi.org/10.3174/ajnr.a1039
Abstract
BACKGROUND AND PURPOSE: In spite of the advent of thrombolytic therapy, CT-perfusion imaging is currently not fully used for clinical decision-making and not included in published clinical guidelines for management of ischemic stroke. We investigated whether lesion volumes on cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) maps predict final infarct volume and whether all these parameters are needed for triage to intravenous recombinant tissue plasminogen activator (rtPA). We also investigated the effect of intravenous rtPA on affected brain by measuring salvaged tissue volume in patients receiving intravenous rtPA and in controls.Keywords
This publication has 11 references indexed in Scilit:
- Door to thrombolysis: ER reorganization and reduced delays to acute stroke treatmentNeurology, 2006
- Perfusion CT and angio CT in the assessment of acute strokeNeuroradiology, 2004
- Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trialsThe Lancet, 2004
- Community-Based Thrombolytic Therapy of Acute Ischemic Stroke in HelsinkiStroke, 2003
- Guidelines for the Early Management of Patients With Ischemic StrokeStroke, 2003
- Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patientsAnnals of Neurology, 2002
- Utility of Perfusion-Weighted CT Imaging in Acute Middle Cerebral Artery Stroke Treated With Intra-Arterial Thrombolysis:Stroke, 2001
- Perfusion Mapping Using Computed Tomography Allows Accurate Prediction of Cerebral Infarction in Experimental Brain IschemiaStroke, 2001
- CT Assessment of Cerebral Perfusion: Experimental Validation and Initial Clinical ExperienceRadiology, 1999
- Functional image of dynamic computed tomography in diagnostic and prognostic evaluation of ischemic stroke within the first 6 hours.Stroke, 1993