Lack of complex I is associated with oncocytic thyroid tumours
Open Access
- 7 April 2009
- journal article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 100 (9), 1434-1437
- https://doi.org/10.1038/sj.bjc.6605028
Abstract
Oncocytic tumours are characterised by hyperproliferation of mitochondria. We immunohistochemically analysed all enzymes of the oxidative phosphorylation system in 19 oncocytic thyroid tumours. A specific lack of complex I was detected, which was expressed at <5% of the level determined in surrounding non-cancerous tissue.Keywords
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