Impact of magnetic resonance imaging on cardiac mortality in thalassemia major
Open Access
- 23 May 2011
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 34 (1), 56-59
- https://doi.org/10.1002/jmri.22621
Abstract
Purpose: To evaluate whether the introduction of magnetic resonance imaging (MRI) in the management of thalassemia major (TM) patients has affected the risk of cardiac death. Materials and Methods: In all, 804 TM patients from two large reference units were included and the risk of dying of cardiac causes, before and after their first MRI, was assessed by a Cox proportional hazards model with time-dependent covariates. Results: Adding information from MRI reduced the risk of cardiac death from 6.0 deaths/1000 patient-years to 3.9 deaths/1000 patient-years (P = 0.22). The risk of cardiac death before having an MRI study was 82% higher compared to the risk observed after the first MRI. Conclusion: MRI has become a vital component of ongoing management and seems to have a beneficial effect on cardiac mortality in TM. J. Magn. Reson. Imaging 2011;.This publication has 19 references indexed in Scilit:
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