Mast cells in asthma – state of the art
- 28 January 2016
- journal article
- review article
- Published by Wiley in Clinical and Experimental Allergy
- Vol. 46 (2), 194-263
- https://doi.org/10.1111/cea.12675
Abstract
Mast cells (MCs) play a central role in tissue homeostasis, sensing the local environment through numerous innate cell surface receptors. This enables them to respond rapidly to perceived tissue insults with a view to initiating a co-ordinated program of inflammation and repair. However, when the tissue insult is chronic, the ongoing release of multiple pro-inflammatory mediators, proteases, cytokines and chemokines leads to tissue damage and remodelling. In asthma, there is strong evidence of ongoing MC activation, and their mediators and cell-cell signals are capable of regulating many facets of asthma pathophysiology. This article reviews the evidence behind this.Keywords
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