Regulation of Foxo‐1 and the angiopoietin‐2/Tie2 system by shear stress
Open Access
- 22 January 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (4), 673-680
- https://doi.org/10.1016/j.febslet.2007.01.028
Abstract
Transcription factor Foxo‐1 can be inactivated via Akt‐mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo‐1 and the Foxo‐1‐dependent, angiogenesis‐related Ang‐2/Tie2‐system are influenced by shear stress in endothelial cells. Expression of Foxo‐1 and its target genes p27Kip1 and Ang‐2 was decreased under shear stress (6 dyn/cm2, 24 h), nuclear exclusion of Foxo‐1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang‐1 expression were detected. In conclusion, Foxo‐1 and Ang‐2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.Keywords
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