The 825C/T polymorphism of G-protein beta3 subunit gene and risk of ischaemic stroke
- 26 May 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Human Hypertension
- Vol. 19 (9), 709-714
- https://doi.org/10.1038/sj.jhh.1001883
Abstract
In this study, we investigated the association of G protein 3 subunit gene (GNB 3) C825T polymorphism with ischaemic stroke and its subtypes in the Chinese Han population in a large case–control study. A total of 990 ischemic stroke patients and 1124 controls were recruited from six medical centres in China. Genotype was determined by polymerase chain reaction and restriction fragment length polymorphism (RFLP) assay. Logistic regression analysis was performed to identify the independent risk factors for stroke. The frequency of 825T carriers is significantly higher in cerebral thrombosis in male subjects (OR=1.35, 95% CI, 1.01–1.82, P=0.046). After further adjustment with traditional risk factors to stroke, the association is not significant. In conclusion, the GNB3 825T allele is not an independent risk factor to ischaemic stroke in the Chinese population.Keywords
This publication has 28 references indexed in Scilit:
- Cumulative Effect of Predisposing Genotypes and Their Interaction With Modifiable Factors on the Risk of Ischemic Stroke in Young AdultsStroke, 2005
- Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in JapaneseBiochemical and Biophysical Research Communications, 2004
- Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic StrokeStroke, 2003
- Fibrinogen Gene Promoter −455 A Allele as a Risk Factor for Lacunar StrokeStroke, 2003
- G Protein β3 Gene Variant, Vascular Function, and Insulin Sensitivity in Type 2 DiabetesHypertension, 2003
- Paraoxonase 192 Gln→Arg PolymorphismStroke, 2002
- G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical StrokeStroke, 2001
- G Protein β3 GeneHypertension, 2000
- G-Protein β 3 Subunit Gene Variant and Left Ventricular Hypertrophy in Essential HypertensionHypertension, 2000
- Stroke in the People’s Republic of ChinaStroke, 1995