Mitigating Mutational Meltdown in Mammalian Mitochondria
Open Access
- 19 February 2008
- journal article
- primer
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 6 (2), e35
- https://doi.org/10.1371/journal.pbio.0060035
Abstract
Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.Keywords
This publication has 32 references indexed in Scilit:
- Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammalsProceedings of the National Academy of Sciences of the United States of America, 2007
- Why Do We Still Have a Maternally Inherited Mitochondrial DNA? Insights from Evolutionary MedicineAnnual Review of Biochemistry, 2007
- Population Size Does Not Influence Mitochondrial Genetic Diversity in AnimalsScience, 2006
- Transitions to Asexuality Result in Excess Amino Acid SubstitutionsScience, 2006
- Time Dependency of Molecular Rate Estimates and Systematic Overestimation of Recent Divergence TimesMolecular Biology and Evolution, 2005
- Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNAScience, 2004
- Estimating the distribution of fitness effects from DNA sequence data: Implications for the molecular clockProceedings of the National Academy of Sciences of the United States of America, 2003
- The Pedigree Rate of Sequence Divergence in the Human Mitochondrial Genome: There Is a Difference Between Phylogenetic and Pedigree RatesAmerican Journal of Human Genetics, 2003
- High Direct Estimate of the Mutation Rate in the Mitochondrial Genome of Caenorhabditis elegansScience, 2000
- Adaptive protein evolution at the Adh locus in DrosophilaNature, 1991