Hypoadiponectinemia as a Predictor for the Development of Hypertension
- 1 June 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 49 (6), 1455-1461
- https://doi.org/10.1161/hypertensionaha.107.086835
Abstract
Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabetic Chinese cohort. A total of 577 subjects (249 men and 328 women) were recruited from the population-based Hong Kong Cardiovascular Risk Factor Prevalence Study and prospectively followed up for 5 years. The relationship of serum adiponectin with the development of hypertension (sitting blood pressure ≥140/90 mm Hg) was investigated in a nested case–control study consisting of 70 subjects who had developed hypertension on follow-up and 140 age- and sex-matched control subjects who were normotensive both at baseline and at year 5. At baseline, serum adiponectin level in the lowest sex-specific tertile was more likely to be associated with hypertension ( P =0.003 versus the highest tertile, after adjusting for age, body mass index, fasting insulin, and high-sensitivity C-reactive protein). At year 5, baseline serum adiponectin was a significant independent predictor of incident hypertension in the nested case–control study ( P =0.015; age adjusted), together with mean arterial pressure ( P P =0.018), and body mass index ( P =0.004). Normotensive subjects with baseline serum adiponectin levels in the lowest sex-specific tertile had an increased risk of becoming hypertensive (adjusted odds ratio: 2.76; 95% CIs: 1.06 to 7.16; P =0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans.Keywords
This publication has 34 references indexed in Scilit:
- C-reactive protein in hypertension: clinical significance and predictive valueNutrition, Metabolism and Cardiovascular Diseases, 2006
- Adiponectin Replenishment Ameliorates Obesity-Related HypertensionHypertension, 2006
- Obesity-Associated HypertensionHypertension, 2005
- Additive Beneficial Effects of Losartan Combined With Simvastatin in the Treatment of Hypercholesterolemic, Hypertensive PatientsCirculation, 2004
- Hypoadiponectinemia Is an Independent Risk Factor for HypertensionHypertension, 2004
- Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureHypertension, 2003
- Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial CellsPublished by Elsevier BV ,2003
- Increased C-reactive protein concentrations in never-treated hypertensionJournal Of Hypertension, 2003
- Association of Hypoadiponectinemia With Impaired VasoreactivityHypertension, 2003
- The prevalence of diabetes, association with cardiovascular risk factors and implications of diagnostic criteria (ADA 1997 and WHO 1998) in a 1996 community‐based population study in Hong Kong ChineseDiabetic Medicine, 2000