Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-α mice
Open Access
- 27 December 2007
- journal article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 9 (6), R91
- https://doi.org/10.1186/bcr1840
Abstract
Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened mammary tumor (MT) latency in MMTV-TGF-α mice with dietary-induced obesity. One link between obesity and breast cancer is the adipokine, leptin. Here, the focus is on diet-induced obesity and MT and mammary fat pad (MFP) leptin and apoptotic signaling proteins.Keywords
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