One-year follow-up study of relapsing-remitting MS patients' cognitive performances: Paced Auditory Serial Addition Test's susceptibility to change
- 14 August 2007
- journal article
- research article
- Published by Cambridge University Press (CUP) in Journal of the International Neuropsychological Society
- Vol. 13 (05), 791-798
- https://doi.org/10.1017/s1355617707071019
Abstract
To evaluate the progression of cognitive decline in multiple sclerosis (MS) patients and the susceptibility of the Multiple Sclerosis Functional Composite (MSFC) Paced Auditory Serial Addition Test (PASAT) to change, we conducted a 1-year follow-up with a comprehensive neuropsychological examination to 19 initially cognitively impaired and 26 cognitively intact relapsing–remitting MS patients, and to 48 healthy controls. The results indicated that the cognitive performance of MS patients remained relatively stable. Healthy controls tended to perform better on most neuropsychological measures at follow-up, the same was not observed in the MS groups. PASAT showed a significant difference between the groups: the cognitively impaired group tended to deteriorate, whereas the control group and the cognitively intact group improved. The change in PASAT could not be explained by the background variables, for example, mood, quality of life, or nervousness. Therefore, the MSFC-PASAT seems to be a sensitive measure to show clinical change in the cognitive status. (JINS, 2007, 13, 791–798.)Keywords
This publication has 35 references indexed in Scilit:
- PASAT in Detecting Cognitive Impairment in Relapsing-Remitting MSApplied Neuropsychology, 2007
- Cognitive, but Not Mood Dysfunction Develops in Multiple Sclerosis during 7 Years of Follow-UpEuropean Neurology, 2004
- Speed of information processing as a key deficit in multiple sclerosis: implications for rehabilitationJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Dual task performance after focal cerebral lesions and closed head injuriesNeuropsychologia, 1996
- Sentence comprehension in multiple sclerosisActa Neurologica Scandinavica, 1995
- Automatic and controlled information processing in multiple sclerosisBrain, 1994
- Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow up study.Journal of Neurology, Neurosurgery & Psychiatry, 1992
- Cognitive dysfunction in multiple sclerosis.Neurology, 1991
- Rating neurologic impairment in multiple sclerosisNeurology, 1983
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983