MicroRNA expression in chronic lymphocytic leukemia developing autoimmune hemolytic anemia
- 29 January 2013
- journal article
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 54 (9), 2016-2022
- https://doi.org/10.3109/10428194.2012.763123
Abstract
Chronic lymphocytic leukemia (CLL) is frequently associated with autoimmune hemolytic anemia (AIHA). However, the mechanisms governing the association between CLL and AIHA are poorly understood. MicroRNAs (miRNAs) have been associated with different clinico-biological forms of CLL and are also known to play a substantial role in autoimmunity. However, there are no studies correlating miRNA expression with the likelihood that patients with CLL will develop AIHA. In this study, we found that malignant B-cells from patients with CLL subsequently developing AIHA present nine down-regulated (i.e. miR-19a, miR-20a, miR-29c, miR-146b-5p, miR-186, miR-223, miR-324-3p, miR-484 and miR-660) miRNAs. Interestingly, two of these miRNAs (i.e. miR-20a and miR-146b-5p) are involved in autoimmune phenomena, and one (i.e. miR-146b-5p) in both autoimmunity and CLL. Furthermore, we demonstrated that miR-146b-5p modulates CD80, a molecule associated with the B-T-cell synapse and in restoration of the antigen presenting cell capacity of CLL cells.This publication has 55 references indexed in Scilit:
- miRBase: integrating microRNA annotation and deep-sequencing dataNucleic Acids Research, 2010
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- The database of experimentally supported targets: a functional update of TarBaseNucleic Acids Research, 2008
- Expression of microRNA‐146 in rheumatoid arthritis synovial tissueArthritis & Rheumatism, 2008
- The prognostic significance of cytopenia in chronic lymphocytic leukaemia/small lymphocytic lymphomaBritish Journal of Haematology, 2008
- Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritisArthritis & Rheumatism, 2008
- MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed PairingMolecular Cell, 2007
- mir-29 regulates Mcl-1 protein expression and apoptosisOncogene, 2007
- NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responsesProceedings of the National Academy of Sciences of the United States of America, 2006
- MicroRNA expression profiles classify human cancersNature, 2005