Surgical management of a large inflammatory periapical lesion with platelet-rich fibrin

Abstract

Periapical inflammatory lesion is the local response of bone around the apex of tooth that develops after the necrosis of the pulp tissue or extensive periodontal disease. The final outcome of the nature of wound healing after endodontic surgery could be repair or regeneration depending on the nature of the wound, the availability of progenitor cells, signaling molecules and microenvironmental cues. The purpose of this case report is to add knowledge to the existing literature about the use of platelet-rich fibrin (PRF) in the treatment of large periapical lesion. A periapical endodontic surgery was performed on a 33-years-old female patient with a swelling in the palatal region of upper front teeth with a large bony defect radiologically. The surgical defect was filled with PRF membrane and sutured. The present case report concluded that PRF produced by high-speed centrifugation accelerated the wound healing and induced the rapid rate of bone formation.