Acoustic Radiation Force Impulse Imaging for Differentiation of Thyroid Nodules
Open Access
- 29 August 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (8), e42735
- https://doi.org/10.1371/journal.pone.0042735
Abstract
Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate sensitivity and specificity of ARFI-imaging for differentiation of thyroid nodules and to compare it to the well evaluated qualitative real-time elastography (RTE). ARFI-imaging involves the mechanical excitation of tissue using acoustic pulses to generate localized displacements resulting in shear-wave propagation which is tracked using correlation-based methods and recorded in m/s. Inclusion criteria were: nodules ≥5 mm, and cytological/histological assessment. All patients received conventional ultrasound, real-time elastography (RTE) and ARFI-imaging. One-hundred-fifty-eight nodules in 138 patients were available for analysis. One-hundred-thirty-seven nodules were benign on cytology/histology, and twenty-one nodules were malignant. The median velocity of ARFI-imaging in the healthy thyroid tissue, as well as in benign and malignant thyroid nodules was 1.76 m/s, 1.90 m/s, and 2.69 m/s, respectively. While no significant difference in median velocity was found between healthy thyroid tissue and benign thyroid nodules, a significant difference was found between malignant thyroid nodules on the one hand and healthy thyroid tissue (p = 0.0019) or benign thyroid nodules (p = 0.0039) on the other hand. No significant difference of diagnostic accuracy for the diagnosis of malignant thyroid nodules was found between RTE and ARFI-imaging (0.74 vs. 0.69, p = 0.54). The combination of RTE with ARFI did not improve diagnostic accuracy. ARFI can be used as an additional tool in the diagnostic work up of thyroid nodules with high negative predictive value and comparable results to RTE.Keywords
This publication has 34 references indexed in Scilit:
- Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility studyUltrasonics, 2012
- Is Elastography Actually Useful in the Presurgical Selection of Thyroid Nodules with Indeterminate Cytology?Journal of Clinical Endocrinology & Metabolism, 2011
- Quantitative Assessment of Normal Soft-Tissue Elasticity Using Shear-Wave Ultrasound ElastographyAmerican Journal of Roentgenology, 2011
- Shear Wave Elastography: A New Ultrasound Imaging Mode for the Differential Diagnosis of Benign and Malignant Thyroid NodulesJournal of Clinical Endocrinology & Metabolism, 2010
- A meta‐analysis of comparing fine‐needle aspiration and frozen section for evaluating thyroid nodulesDiagnostic Cytopathology, 2008
- Differential Diagnosis of Benign and Malignant Thyroid Nodules at ElastosonographyUltraschall in der Medizin - European Journal of Ultrasound, 2008
- US-Elastography in the Differential Diagnosis of Benign and Malignant Thyroid NodulesThyroid®, 2008
- Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-AnalysisGastroenterology, 2008
- Value of Repeated Fine Needle Aspirations of the Thyroid: An Analysis of Over Ten Thousand FNAsThyroid®, 2007
- Vascularisation of Benign and Malignant Thyroid Nodules: CD US EvaluationUltraschall in der Medizin - European Journal of Ultrasound, 2007