Genetics of epilepsy syndromes in families with photosensitivity
- 2 April 2013
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 80 (14), 1322-1329
- https://doi.org/10.1212/wnl.0b013e31828ab349
Abstract
Objective: To use family studies to investigate the clinical genetics of photosensitivity to understand the interrelationship of different photosensitive epilepsy syndromes. Methods: Twenty-nine families were recruited in which at least 2 members had idiopathic epilepsy and either clinical or electrical photosensitivity on EEG studies. We performed electroclinical analysis of these individuals and all other affected family members and analyzed the phenotypic patterns in families. Results: An earlier age at seizure onset was observed in photosensitive patients compared with nonphotosensitive individuals. A significant female bias for photosensitivity was confirmed. All subjects with visual seizures were photosensitive. Subjects could be classified into 3 main photosensitive phenotypes: genetic (idiopathic) generalized epilepsies (GGE), idiopathic photosensitive occipital epilepsy (IPOE), and mixed GGE/IPOE. Within each category, subjects with purely photosensitive seizures were observed. We report a distinctive syndrome of early-onset photosensitive absence epilepsy, with onset beginning by 4 years of age, which was more refractory than childhood absence epilepsy. Conclusions: The clinical genetics of the idiopathic photosensitive epilepsies show a phenotypic spectrum from the GGEs to IPOE with overlap between the focal features of IPOE and all the GGE syndromes. Shared genetic determinants are likely to contribute to the complex inheritance pattern of photosensitivity, IPOE, and the GGEs.Keywords
This publication has 35 references indexed in Scilit:
- Is Photosensitive Epilepsy Less Common in Males Due to Variation in X Chromosome Photopigment Genes?Epilepsia, 2007
- NEDD4‐2 as a potential candidate susceptibility gene for epileptic photosensitivityGenes, Brain and Behavior, 2007
- Early-onset absence epilepsy: Clinical and electroencephalographic features in three childrenBrain & Development, 2006
- Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsyAnnals of Neurology, 2005
- Juvenile myoclonic epilepsy and idiopathic photosensitive occipital lobe epilepsy: is there overlap?Brain, 2004
- Clinical and EEG Asymmetries in Juvenile Myoclonic EpilepsyEpilepsia, 1994
- Concordance of Clinical Forms of Epilepsy in Families with Several Affected MembersEpilepsia, 1993
- Nosological Problems of Myoclonic Epilepsies in Childhood and AdolescenceDevelopmental Medicine and Child Neurology, 1977
- Centrencephalic Myoclonic-Astatic Petit Mal1– Clinical and genetic investigationsNeuropediatrics, 1970
- Analysis of the Electrical Response of the Human Cortex to Photic StimulationNature, 1946