ASSEMBLY OF VARIANT HISTONES INTO CHROMATIN
- 1 November 2005
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 21 (1), 133-153
- https://doi.org/10.1146/annurev.cellbio.21.012704.133518
Abstract
Chromatin can be differentiated by the deposition of variant histones at centromeres, active genes, and silent loci. Variant histones are assembled into nucleosomes in a replication-independent manner, in contrast to assembly of bulk chromatin that is coupled to replication. Recent in vitro studies have provided the first glimpses of protein machines dedicated to building and replacing alternative nucleosomes. They deposit variant H2A and H3 histones and are targeted to particular functional sites in the genome. Differences between variant and canonical histones can have profound consequences, either for delivery of the histones to sites of assembly or for their function after incorporation into chromatin. Recent studies have also revealed connections between assembly of variant nucleosomes, chromatin remodeling, and histone post-translational modification. Taken together, these findings indicate that chromosome architecture can be highly dynamic at the most fundamental level, with epigenetic consequences.Keywords
This publication has 101 references indexed in Scilit:
- Progress and challenges in profiling the dynamics of chromatin and transcription factor binding with DNA microarraysCurrent Opinion in Genetics & Development, 2004
- Evidence for nucleosome depletion at active regulatory regions genome-wideNature Genetics, 2004
- From Silencing to Gene Expression: Real-Time Analysis in Single CellsCell, 2004
- The Crystal Structure of AF1521 a Protein from Archaeoglobus fulgidus with Homology to the Non-histone Domain of MacroH2AJournal of Molecular Biology, 2003
- Solvent Mediated Interactions in the Structure of the Nucleosome Core Particle at 1.9Å ResolutionJournal of Molecular Biology, 2002
- Translating the Histone CodeScience, 2001
- A Novel Chromatin Immunoprecipitation and Array (CIA) Analysis Identifies a 460-kb CENP-A-Binding Neocentromere DNAGenome Research, 2001
- Changes in histones H2A and H3 variant composition in differentiating and mature rat brain cortical neuronsDevelopmental Biology, 1987
- Changes in nucleosomal core histone variants during chicken development and maturationDevelopmental Biology, 1983
- Studies on histone organization in the nucleosome using formaldehyde as a reversible cross-linking agentCell, 1978