Pregnancy in Renal Transplant Recipients: Long-Term Effect on Patient and Graft Survival. A Single-Center Experience
- 15 March 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Transplantation
- Vol. 81 (5), 660-664
- https://doi.org/10.1097/01.tp.0000166912.60006.3d
Abstract
There are limited data on the effect of pregnancy on long-term renal allograft function. The aim of the study was to compare long-term graft and patient outcome between pregnant and nonpregnant women after renal transplantation.The study group consisted of 39 women attending the Perinatal Division of the Rabin Medical Center who conceived after undergoing renal transplantation (total number of live births: 55). All had a functioning allograft at the time of conception. Each patient was matched with 3 controls for 12 factors known to affect graft survival. The controls were derived from a cohort of 250,000 transplant patients registered in the Collaborative Transplantation Study (CTS) database. The groups were compared for graft survival, long-term patient survival, and kidney function (CTS clinical grading scale).Graft (61.6%) and patient (84.8 %) survival from transplantation to the end of follow-up (15 years) in the women who conceived after transplantation did not differ from the rates observed in the 177 women in the matched control group (68.7% and 78.8 %, respectively). There were no between-group differences in long-term graft function.Pregnancy does not appear to have adverse effects on long-term graft or patient survival or kidney function in women after renal transplantation.This publication has 19 references indexed in Scilit:
- Is immunosuppression therapy in renal allograft recipients teratogenic? A single-center experienceAmerican Journal of Medical Genetics, 2002
- Repeated successful pregnancies after kidney transplantation in 102 women (Report by the EDTA RegistryNephrology Dialysis Transplantation, 1996
- Repeated successful pregnancies after kidney transplantation in 102 women (Report by the EDTA RegistryNephrology Dialysis Transplantation, 1996
- Effect of pregnancy on the long-term function of renal allografts: An updateAmerican Journal of Kidney Diseases, 1995
- VARIABLES AFFECTING BIRTHWEIGHT AND GRAFT SURVIVAL IN 197 PREGNANCIES IN CYCLOSPORINE-TREATED FEMALE KIDNEY TRANSPLANT RECIPIENTS1,2Transplantation, 1995
- LACK OF EFFECT OF PREGNANCY ON RENAL ALLOGRAFT SURVIVAL OR FUNCTION1Transplantation, 1995
- Towards long-term graft survival in renal transplantation: pregnancyNephrology Dialysis Transplantation, 1995
- NATIONAL TRANSPLANTATION PREGNANCY REGISTRY—OUTCOMES OF 154 PREGNANCIES IN CYCLOSPORINE-TREATED FEMALE KIDNEY TRANSPLANT RECIPIENTSTransplantation, 1994
- IMPAIRED RENAL FUNCTION AFTER PREGNANCY IN RENAL TRANSPLANT RECIPIENTS1Transplantation, 1993
- The effect of pregnancy on kidney function in renal allograft recipientsKidney International, 1985