Melatonin delays photoreceptor degeneration in the rds/rds mouse
- 1 April 2001
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 12 (5), 1011-1014
- https://doi.org/10.1097/00001756-200104170-00029
Abstract
Photoreceptors in retinitis pigmentosa (RP), a group of inherited retinal degenerative diseases, die through apoptosis. Since melatonin protects against neuronal apoptotic death, we tested its ability to slow photoreceptor degeneration in the rds/rds mouse, an animal model for RP. Shortly after birth, rds/rds mice were given daily i.p. injections of melatonin or vehicle for 11 weeks. Melatonin treatment significantly delayed photoreceptor loss and reduced the number of apoptotic photoreceptors. Further studies should determine if melatonin will have potential for the treatment of certain human retinal degenerations.Keywords
This publication has 20 references indexed in Scilit:
- Retinitis Pigmentosa: Defined From a Molecular Point of ViewSurvey of Ophthalmology, 1999
- Adenovirus-mediated delivery of rhodopsin-promoted bcl-2 results in a delay in photoreceptor cell death in the rd/rd mouseGene Therapy, 1998
- Melatonin's Role in Vertebrate Orcadian RhythmsChronobiology International, 1998
- Protective effect of melatonin against hippocampal dna damage induced by intraperitoneal administration of kainate to ratsNeuroscience, 1996
- The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytesJournal of Pineal Research, 1995
- Bcl-2 functions in an antioxidant pathway to prevent apoptosisCell, 1993
- Melatonin: Parallels in pineal gland and retinaExperimental Eye Research, 1986
- Melatonin is a potent modulator of dopamine release in the retinaNature, 1983
- Methoxyindoles and Photoreceptor Metabolism: Activation of Rod SheddingScience, 1983
- Absence of receptor outer segments in the retina of rds mutant miceNeuroscience Letters, 1981