Analysis of the concentration–respiratory response among asthmatics following controlled short-term exposures to sulfur dioxide
- 18 November 2010
- journal article
- research article
- Published by Informa UK Limited in Inhalation Toxicology
- Vol. 22 (14), 1184-1193
- https://doi.org/10.3109/08958378.2010.535220
Abstract
Some of the most compelling evidence of sulfur dioxide (SO2)-induced respiratory morbidity is derived from a large body of studies involving controlled short-term exposures among groups of asthmatic volunteers. These studies were extensively cited in the recently completed review of the primary National Ambient Air Quality Standards for SO2. Although it is clear from these investigations that exposure to SO2 may result in a significant increase in bronchoconstriction, there is uncertainty regarding the range of concentrations over which this respiratory response occurs. The objective of this study was to better characterize the concentration–response relationship between SO2 and measures of bronchoconstriction using individual subject lung function response data. In reviewing studies of asthmatics exposed to SO2 during 5- to 10-min periods of elevated ventilation, we observed clear and consistent evidence of an increase in the bronchoconstrictive response to SO2 with increasing exposure concentrations between 0.2 and 1.0 ppm. In a subsequent analysis of individual subject data, it was found that those asthmatics experiencing SO2-induced respiratory effects at relatively high exposure concentrations are also more likely than nonresponders to experience similar effects after exposure to lower SO2 concentrations (≤0.4 ppm). Although the clinical significance of these effects is unsettled, the findings provide additional support to epidemiologic evidence of an association between ambient SO2 concentration and various measures of respiratory morbidity in the general population.Keywords
This publication has 22 references indexed in Scilit:
- Symptom Perception in Pediatric AsthmaChest, 2007
- Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limitsInternationales Archiv für Arbeitsmedizin, 2005
- Anti-inflammatory and Lung Function Effects of Montelukast in Asthmatic Volunteers Exposed to Sulfur DioxideChest, 2001
- Symptom Perception and Respiratory Sensation in AsthmaAmerican Journal of Respiratory and Critical Care Medicine, 2000
- What Constitutes an Adverse Health Effect of Air Pollution?American Journal of Respiratory and Critical Care Medicine, 2000
- Effect of Inhaled Salmeterol on Sulfur Dioxide-Induced Bronchoconstriction in Asthmatic SubjectsChest, 1996
- Comparative Short-Term Health Responses To Sulfur Dioxide Exposure and Other Common Stresses in a Panel of AsthmaticsToxicology and Industrial Health, 1995
- Symptomatic Bronchoconstriction after Short-Term Inhalation of Sulfur DioxideAmerican Review of Respiratory Disease, 1987
- Effect of 0.25 ppm Sulfur Dioxide on Airway Resistance in Freely Breathing, Heavily Exercising, Asthmatic SubjectsAmerican Review of Respiratory Disease, 1985
- Time course of exercise-induced bronchoconstriction in asthmatics exposed to sulfur dioxideEnvironmental Research, 1984