Longitudinal Studies of Cognition in First Episode Psychosis: A Systematic Review of the Literature
- 1 February 2011
- journal article
- review article
- Published by SAGE Publications in Australian & New Zealand Journal of Psychiatry
- Vol. 45 (2), 93-108
- https://doi.org/10.3109/00048674.2010.541418
Abstract
Although cognitive deficits are recognized as a core feature in schizophrenia, their evolution over the course of the illness is still debated. Longitudinal studies of cognition in patients after a first episode of psychosis (FEP) provide extremely useful information, in that they include an adequate and realistic baseline measure of cognitive performance, while at the same time minimizing the effect of confounding variables associated with chronicity. The aim of this systematic review was to summarize findings of studies assessing the longitudinal course of neuropsychological deficits in patients with FEP for durations of at least one year. Overall, the neuropsychological deficits that are present following a first episode of psychosis appeared to remain stable over time for periods of up to ten years, the only possible exception being verbal memory deficits, where there is some evidence of further deterioration over the long term. However, further studies are needed to confirm this conclusion, especially in the (somewhat inconsistently defined) domain of executive function. Improvements in psychopathology appear to positively influence the course of cognitive deficits, although the effects of antipsychotic medication are not as clear.Keywords
This publication has 81 references indexed in Scilit:
- Course of neurocognitive deficits in the prodrome and first episode of schizophrenia.Neuropsychology, 2010
- Discrimination Learning, Reversal, and Set-Shifting in First-Episode Schizophrenia: Stability Over Six Years and Specific Associations with Medication Type and Disorganization SyndromeBiological Psychiatry, 2009
- IQ as a predictor of functional outcome in schizophrenia: A longitudinal, four-year study of first-episode psychosisSchizophrenia Research, 2009
- 1-year follow-up study of cognitive function in first-episode non-affective psychosisSchizophrenia Research, 2008
- Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and NeuroprotectionPharmacological Reviews, 2008
- Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitationSchizophrenia Research, 2008
- What Happens After the First Episode? A Review of Progressive Brain Changes in Chronically Ill Patients With SchizophreniaSchizophrenia Bulletin, 2007
- The course of neurocognitive functioning in first-episode psychosis and its relation to premorbid adjustment, duration of untreated psychosis, and relapseSchizophrenia Research, 2007
- The Consortium on the Genetics of Schizophrenia: Neurocognitive EndophenotypesSchizophrenia Bulletin, 2006
- Measuring Changes in Functional Status Among Patients With Schizophrenia: The Link With Cognitive ImpairmentSchizophrenia Bulletin, 2005