Fatigue in patients with neuromyelitis optica spectrum disorder and its impact on quality of life
Open Access
- 23 May 2017
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 12 (5), e0177230
- https://doi.org/10.1371/journal.pone.0177230
Abstract
Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), a severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue and quality of life (QOL). We aimed to evaluate the severity of fatigue and its relationship with QOL in patients with NMOSD. We prospectively studied patients with NMOSD who were in remission and seropositive for anti-aquaporin-4 antibody, and they were divided into 2 groups based on the presence of fatigue assessed using the Functional Assessment of Chronic Illness Therapy-fatigue score. Sleep quality, depression, pain, and QOL were also evaluated. A total of 35 patients were enrolled (mean age, 46.5 ± 14.1 years; female: male = 29:6), and the median Expanded Disability Status Scale (EDSS) score was 2.0 (range, 0 to 8.0). The patients with fatigue (N = 25, 71.4%) had poorer sleep quality and more severe depression than those without fatigue (p = 0.009 and p = 0.001). Both the physical and mental QOL scores were lower in patients with fatigue than in those without fatigue (p = 0.033 and p = 0.004). Multiple linear regression analyses showed that the degree of fatigue with EDSS score and pain were independent predictors of physical aspects of QOL (B = 0.382, p = 0.001), whereas depression was the only predictor of the mental components of QOL (B = -0.845, p = <0.001). Fatigue is a common symptom and an important predictor of QOL in patients with NMOSD.Keywords
This publication has 45 references indexed in Scilit:
- Poor Sleep in Patients with Multiple SclerosisPLOS ONE, 2012
- Clinical Usefulness of Cell-based Indirect Immunofluorescence Assay for the Detection of Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum DisorderAnnals of Laboratory Medicine, 2012
- Validation of the Functional Assessment of Chronic Illness Therapy-Fatigue Scale in Patients with Moderately to Severely Active Systemic Lupus Erythematosus, Participating in a Clinical TrialThe Journal of Rheumatology, 2011
- A five-year prospective study of fatigue in primary Sjögren's syndromeArthritis Research & Therapy, 2011
- Self-reported fatigue: one dimension or more? Lessons from the Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F) questionnaireSupportive Care in Cancer, 2010
- Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing—remitting multiple sclerosisMultiple Sclerosis Journal, 2010
- Multiple sclerosis related fatigueJournal of Neurology, Neurosurgery & Psychiatry, 2006
- Involvement and Role of the Hypothalamo-pituitary-adrenal (HPA) Stress Axis in Animal Models of Chronic Pain and InflammationStress, 2004
- Fatigue in multiple sclerosis: relationship to depression, disability, and disease patternMultiple Sclerosis Journal, 2000
- Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement systemJournal of Pain and Symptom Management, 1997