Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China
- 2 October 2007
- journal article
- Published by Springer Science and Business Media LLC in Zeitschrift für Parasitenkunde
- Vol. 102 (1), 83-90
- https://doi.org/10.1007/s00436-007-0727-0
Abstract
The prevalence and geographical distribution of the intestinal protozoa Blastocystis in humans across China is unknown, and the relative importance of different subtypes has yet to be investigated. We assessed the community prevalence and relative frequencies of different Blastocystis subtypes in four epidemiological settings in China, i.e., Shanghai municipality, Yongjia county (Zhejiang province), Eryuan county, and Menghai county (both Yunnan province). Blastocystis infection was detected with the culture method, and the subtype was identified with polymerase chain reaction using a set of subtype-specific primers. The prevalence at the four study settings was 1.9, 5.9, 18.4, and 32.6%, respectively. People aged greater than or equal to 60 years had a higher prevalence in the former two settings, Shanghai and Yongjia, whereas the highest infection rate was found among individuals aged 10–17 years in the latter two settings, Eryuan and Menghai. A higher prevalence was found in men in the former two settings but in women in the latter two settings. Five different Blastocystis subtypes were identified from the 192 isolates. Subtype 3 was the predominant type, followed by subtype 1. In conclusion, the epidemiology of Blastocystis varies across China.Keywords
This publication has 95 references indexed in Scilit:
- Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical IntegrationFrontiers in Oncology, 2013
- Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcomaEuropean Journal of Cancer, 2012
- High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenesCancer, 2011
- Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivoCancer, 2011
- Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cellsProceedings of the National Academy of Sciences of the United States of America, 2009
- Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumorsCancer, 2008
- Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsOncogene, 2008
- Genetic variability of Blastocystis hominis isolates in ChinaZeitschrift für Parasitenkunde, 2006
- Exploiting the PI3K/AKT Pathway for Cancer Drug DiscoveryNature Reviews Drug Discovery, 2005
- Polymerase chain reaction-based genotype classification among human Blastocystis hominis populations isolated from different countriesZeitschrift für Parasitenkunde, 2004