Thromboembolic disease in vasculitis
- 1 January 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Rheumatology
- Vol. 21 (1), 41-46
- https://doi.org/10.1097/bor.0b013e32831de4e7
Abstract
Purpose of review To give an overview of recent clinical findings of thromboembolic disease in vasculitis and provide insight into possible explanations of the association between thrombosis and inflammation. Recent findings A high incidence of venous thrombotic events has recently been described in four distinct cohorts of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), especially during periods of active disease. No factors other than the vasculitis itself have been identified that explain this high occurrence of thrombosis. Several studies have shown an increased rate of thrombosis in Behçet's disease, with a different clinical presentation from that observed in AAV. Recent laboratory findings provide exciting insights into a bidirectional feedback loop between coagulation and inflammation that may be applicable to vasculitis. Summary Thrombosis is an important clinical manifestation of some types of vasculitis. Better understanding of the association of thrombosis with inflammation in vasculitis might lead to development of clinically useful biomarkers and new approaches to therapy. Additionally, study of the specific factors involved in thrombosis in systemic vasculitis could help explain the role of inflammation in more common settings of venous thrombotic events.Keywords
This publication has 63 references indexed in Scilit:
- Polyarteritis Nodosa Complicated by Antiphospholipid SyndromeSouthern Medical Journal, 2008
- Treatment of venous thrombosis associated with Behcet’s disease: immunosuppressive therapy alone versus immunosuppressive therapy plus anticoagulationClinical Rheumatology, 2007
- Carotid and Coronary Artery Occlusion in a Patient With Takayasu ArteritisJournal of Cardiac Surgery, 2007
- Lupus Anticoagulant and Thrombosis Following Henoch-Schönlein PurpuraPediatric Neurology, 2007
- Polyarteritis Nodosa Complicated by Catastrophic Antiphospholipid SyndromeJCR: Journal of Clinical Rheumatology, 2004
- Design of the Wegener's Granulomatosis Etanercept Trial (WGET)Controlled Clinical Trials, 2002
- Primary antiphospholipid syndrome presenting as complicated Henoch-Schonlein purpuraArchives of Disease in Childhood, 2002
- Polyarteritis nodosa complicated by thrombotic thrombocytopenic purpuraAnnals Of The Rheumatic Diseases, 2001
- Behçet's Disease in Kuwait, Arabia:A report of 29 Cases and a ReviewScandinavian Journal of Rheumatology, 1986
- Fate of coronary aneurysms in Kawasaki disease: Serial coronary angiography and long-term follow-up studyThe American Journal of Cardiology, 1982