A human inhibitor of tumor necrosis factor alpha.
Open Access
- 1 April 1988
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 167 (4), 1511-1516
- https://doi.org/10.1084/jem.167.4.1511
Abstract
Urine of some febrile patients exhibits a TNF-alpha inhibitory activity (TNF-alpha INH), sensitive to heat and trypsin, with an apparent mol wt of 40-60 X 10(3) and a pI range of 5.5-6.1. As for the Il-1 INH, the TNF INH activity involves a competitive mechanism of action suggesting the existence of a family of negative feedback-regulating molecules interfering with cytokines actions.Keywords
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