FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor
- 1 June 1990
- journal article
- inflammation and-immunomodulation
- Published by Springer Science and Business Media LLC in Inflammation Research
- Vol. 30 (3-4), 432-442
- https://doi.org/10.1007/bf01966309
Abstract
FLP 62064 [N-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-3-amine] is a dual inhibitor of prostaglandin synthetase and 5-lipoxygenase. The compound had anti-inflammatory activityin vivo in a number of models. It inhibited peritoneal inflammation induced by immune-complex when given locally. When applied to the skin, FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.Keywords
This publication has 24 references indexed in Scilit:
- Pharmacological modification of 12-O-tetradecanoylphorbol-13-acetate induced inflammation and epidermal cell proliferation in mouse skinInflammation Research, 1988
- Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase CNature, 1987
- Psoriatic science.BMJ, 1987
- Enzymic lipoxygenation of arachidonic acid: mechanism, inhibition, and role in eicosanoid biosynthesisPure and Applied Chemistry, 1987
- Immune complex mediated inflammation in the mouse peritoneal cavity: A method for investigating inhibitors of arachidonate metabolismJournal of Pharmacological Methods, 1986
- Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agentsInflammation Research, 1985
- Models for evaluating the anti-inflammatory effects of inhibitors of arachidonic acid metabolismJournal of Pharmacy and Pharmacology, 1985
- The effect of BW 54oC, a novel anti-inflammatory agent, on ultraviolet-induced physical and histological changes in guinea-pig skinBritish Journal of Dermatology, 1985
- Cyclosporin a inhibits biological effects of tumor promoting phorbol estersBiochemical and Biophysical Research Communications, 1985
- PSORIASIS AND LEUKOTRIENE B4The Lancet, 1982