Embryologic origin of endometriosis: Analysis of 101 human female fetuses
- 15 June 2011
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 227 (4), 1653-1656
- https://doi.org/10.1002/jcp.22888
Abstract
The etiology of endometriosis, a gynecological disease characterized by the presence of endometrial glands and stroma outside the uterine cavity, is still unknown. Our research group has recently demonstrated the presence of ectopic endometrium in human female fetuses at different gestational ages. In this manuscript we describe four new cases of fetal endometriosis found among a series of 52 female fetuses analyzed at autopsy. The anatomical localization of this ectopic endometrium, and its histological and immunohistochemical characteristics are depicted. We suggest that endometriosis is caused by dislocation of primitive endometrial tissue outside the uterine cavity during organogenesis. The clinical and pathological implications of these findings are discussed. J. Cell. Physiol. 227: 1653–1656, 2012.This publication has 30 references indexed in Scilit:
- EndometriosisThe New England Journal of Medicine, 2009
- Histological Confirmation of Endometriosis in a 9-Year-Old Girl Suffering from Unexplained Cyclic Pelvic Pain since Her Eighth Year of LifeGynecologic and Obstetric Investigation, 2008
- Environmental Estrogens and Endocrine Disruption: Importance of Comparative EndocrinologyEndocrinology, 2008
- Endometriosis: Pathogenesis, diagnosis, therapy and association with cancer (Review)Oncology Reports, 2008
- History of adenomyosisBest Practice & Research Clinical Obstetrics & Gynaecology, 2006
- EndometriosisThe Lancet, 2004
- Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogyJournal of Pediatric and Adolescent Gynecology, 2003
- Adenomyosis in a patient with the Rokitansky-Kuster-Hauser syndromeFertility and Sterility, 2000
- The Maine Womenʼs Health StudyObstetrics & Gynecology, 1994
- Endometriosis and Genital Anomalies:Some Histogenetic Aspects of External EndometriosisGynecologic and Obstetric Investigation, 1986