Contrast enhanced-cardiovascular magnetic resonance imaging in patients with pulmonary hypertension
Open Access
- 17 May 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 26 (19), 1993-1999
- https://doi.org/10.1093/eurheartj/ehi328
Abstract
Aims To determine the presence and extent of delayed contrast enhancement (DCE) in patients with pulmonary hypertension (PHT) using contrast enhanced-cardiovascular magnetic resonance imaging (ce-CMR). Methods and results Twenty-five patients with PHT underwent ce-CMR and right heart catheterization. Right ventricular (RV) and left ventricular (LV) volumes, ejection fraction, mass, and DCE mass were determined with ce-CMR. Mean pulmonary artery pressure (mean PAP) averaged 43 (12) mmHg and cardiac output 4.3 (1.2) L/min. DCE was demonstrated in 23 out of 25 patients. DCE was confined to the RV insertion points (RVIPs) in seven patients and extended into the interventricular septum (IVS) in the remaining 16 patients. In these 16 patients, septal contrast enhancement was associated with IVS bowing. The extent of contrast enhancement correlated positively with RV end-diastolic volume/body surface area, RV mass, mean PAP, and pulmonary vascular resistance and correlated inversely with RV ejection fraction. Conclusion DCE was present within the RVIPs and IVS of most patients with PHT studied. Extent of DCE correlated with RV function and pulmonary haemodynamics. DCE was associated with IVS bowing and may provide a novel marker for occult septal abnormalities directly relating to the haemodynamic stress experienced by these patients.Keywords
This publication has 27 references indexed in Scilit:
- Delayed contrast enhancement of MRI in hypertrophic cardiomyopathyMagnetic Resonance Imaging, 2004
- MRI of Acute MyocarditisChest, 2002
- Pulmonary Arterial Resistance: Noninvasive Measurement with Indexes of Pulmonary Flow Estimated at Velocity-encoded MR Imaging—Preliminary ExperienceRadiology, 1999
- MRI evaluation of right ventricular pressure overload in chronic obstructive pulmonary diseaseJournal of Magnetic Resonance Imaging, 1998
- Estimation of right ventricular mass in normal subjects and in patients with primary pulmonary hypertension by nuclear magnetic resonance imagingJournal of the American College of Cardiology, 1993
- Comparison of magnetic resonance imaging studies with enzymatic indexes of myocardial necrosis for quantification of myocardial infarct sizeThe American Journal of Cardiology, 1993
- Direct quantitation of right and left ventricular volumes with nuclear magnetic resonance imaging in patients with primary pulmonary hypertensionJournal of the American College of Cardiology, 1992
- Pulmonary hypertension: pulmonary flow quantification and flow profile analysis with velocity-encoded cine MR imaging.Radiology, 1992
- Survival in Patients with Primary Pulmonary HypertensionAnnals of Internal Medicine, 1991
- Natural history of pulmonary hemodynamics in primary pulmonary hypertensionAmerican Heart Journal, 1987