Enzymatic Total Synthesis of Rabelomycin, an Angucycline Group Antibiotic
- 20 May 2010
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (12), 2814-2817
- https://doi.org/10.1021/ol1009009
Abstract
A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.Keywords
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