Calculation of high-LET radiotherapy dose required for compensation of overall treatment time extensions
- 1 March 2006
- journal article
- Published by Oxford University Press (OUP) in The British Journal of Radiology
- Vol. 79 (939), 254-257
- https://doi.org/10.1259/bjr/49977661
Abstract
A method is presented that allows biological effective dose (BED) equations to be used to calculate compensatory doses for treatment time extensions when high-LET (linear energy transfer) radiotherapy schedules are used. The principles involved are the same as those for low-LET radiations, but incorporate two relative biological effectiveness (RBE) factors, RBEmax and RBEmin, which represent the RBE at very low and very high fraction doses, respectively, with the actual RBE changing between these extremes. The method has the advantage that low-LET α/β ratios and low-LET daily dose-equivalent repopulation factors are used in the calculations. The daily dose repopulation equivalents and increments in dose per fraction in the case of high LET radiotherapy are smaller than those for low LET.Keywords
This publication has 11 references indexed in Scilit:
- Overview of clinical experiences on carbon ion radiotherapy at NIRSRadiotherapy and Oncology, 2004
- Results of carbon ion radiotherapy in 152 patientsInternational Journal of Radiation Oncology*Biology*Physics, 2004
- Practical Methods for Compensating for Missed Treatment Days in Radiotherapy, with Particular Reference to Head and Neck SchedulesClinical Oncology, 2002
- Relative biological effectiveness (RBE) values for proton beam therapyInternational Journal of Radiation Oncology*Biology*Physics, 2002
- The Role of Biologically Effective Dose (BED) in Clinical OncologyClinical Oncology, 2001
- Estimation of optimum dose per fraction for high LET radiations: Implications for proton radiotherapyInternational Journal of Radiation Oncology*Biology*Physics, 2000
- Dose equivalents of tumour repopulation during radiotherapy: the potential for confusion.The British Journal of Radiology, 2000
- The linear-quadratic formula and progress in fractionated radiotherapyThe British Journal of Radiology, 1989
- Dose fractionation, dose rate and iso-effect relationships for normal tissue responsesInternational Journal of Radiation Oncology*Biology*Physics, 1982