Alveolar Soft Part Sarcoma in Japan: Multi-Institutional Study of 57 Patients from the Japanese Musculoskeletal Oncology Group
- 1 July 2003
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 65 (1), 7-13
- https://doi.org/10.1159/000071199
Abstract
Objective: The clinical features and the management of alveolar soft part sarcoma (ASPS) are not well known. The efficacy of chemotherapy for soft tissue sarcoma, including high-dose ifosfamide and cisplatin, has not been established yet. Some reports suggest ASPS may occur primarily in bone. Methods: We report on a series of 57 patients with ASPS over 20 years. Their ages ranged from 7 to 75 years (mean 25). Results: There were 37 females and 20 males. Thirteen lesions (23%) showed bone involvement at the primary site, and 6 of them were diagnosed as bone tumors at presentation. Thirty-seven patients had distant metastases at presentation. Tumor size, bone involvement at the primary site and the presence of metastases at presentation were prognostic indicators (p < 0.05). Marginal excision with radiotherapy or wide excision without radiotherapy achieved good local control. Chemotherapy was performed in 47 patients with different regimens. Two patients treated with intra-arterial chemotherapy regimens responded partially, but intravenous chemotherapy with high-dose ifosfamide or cisplatin failed. Conclusions: ASPS can present primarily as a bone tumor. No advantage of chemotherapy with high-dose ifosfamide or cisplatin could be demonstrated.Keywords
This publication has 6 references indexed in Scilit:
- Alveolar soft part sarcoma with lung metastases. Response to interferon alpha‐2a?Medical and Pediatric Oncology, 2001
- Alveolar soft part sarcomaCancer, 2001
- The efficacy of a combination of etoposide, ifosfamide, and cisplatin in the treatment of patients with soft tissue sarcomaCancer, 2000
- Primary alveolar soft part sarcoma of boneHistopathology, 1999
- Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft‐part sarcomaCancer, 1999
- Alveolar soft part sarcoma in children and adolescents: Clinical features and outcome of 11 patientsMedical and Pediatric Oncology, 1996