Bacteremic Elder Emergency Department Patients: Procalcitonin and White Count
Open Access
- 1 April 2004
- journal article
- research article
- Published by Wiley in Academic Emergency Medicine
- Vol. 11 (4), 393-396
- https://doi.org/10.1197/j.aem.2003.10.027
Abstract
To assess serum procalcitonin (PCT) and white blood cell (WBC) count in detecting bacteremia in elder emergency department (ED) patients. A prospective, observational study of ED patients aged > or =65 years in whom blood cultures were drawn was conducted at an urban, tertiary care, academic ED. Serum for PCT and WBC count was obtained at the time of ED visit. Receiver-operating characteristic (ROC) curves, proportions, and likelihood ratios were calculated. One hundred eight patients met entry criteria, 14 with bacteremia. In comparing bacteremic patients versus all others, PCT > 0.2 ng/mL was 93% sensitive (95% confidence interval [CI] = 79% to 100%) and 38% specific (95% CI = 28% to 48%) with a negative likelihood ratio (LR(-)) of 0.18. Abnormal WBC count was 64% sensitive (95% CI = 39% to 89%) and 54% specific (95% CI = 44% to 64%) with an LR(-) of 0.78. The presence of either abnormal WBC count or left shift was 93% sensitive (95% CI = 74% to 100%) but 11% specific (95% CI = 4% to 11%) with an LR(-) of 0.64. When considering only bacteremic patients versus noninfected patients, PCT at a cutoff of 0.2 ng/mL had an LR(-) of 0.12. Area under a ROC curve was significantly greater for PCT (0.7; 95% CI = 0.6 to 0.9) than for abnormal WBC count (0.5; 95% CI = 0.3 to 0.7; p < 0.05). In elder ED patients, a PCT level of 0.2 ng/mL is sensitive for bacteremia and, based on its negative likelihood ratio, is moderately helpful in ruling out the diagnosis. WBC count with or without left shift performed poorly in the diagnosis of bacteremia.Keywords
This publication has 11 references indexed in Scilit:
- Low Serum Procalcitonin Level Accurately Predicts the Absence of Bacteremia in Adult Patients with Acute FeverClinical Infectious Diseases, 2002
- Diagnostic value of procalcitonin levels as an early indicator of sepsisThe American Journal of Emergency Medicine, 2002
- Usefulness of Procalcitonin as a Marker of Systemic Infection in Emergency Department Patients: A Prospective StudyClinical Infectious Diseases, 2002
- Usefulness of Procalcitonin Serum Level for the Diagnosis of BacteremiaEuropean Journal of Clinical Microbiology & Infectious Diseases, 2001
- Early identification of bacteremia by biochemical markers of systemic inflammationScandinavian Journal of Clinical and Laboratory Investigation, 2001
- Calcitonin precursors are reliable markers of sepsis in a medical intensive care unitCritical Care Medicine, 2000
- Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrationsCritical Care Medicine, 1997
- Difficulty in predicting bacteremia in elderly emergency patientsAnnals of Emergency Medicine, 1992
- A method of comparing the areas under receiver operating characteristic curves derived from the same cases.Radiology, 1983