Vitiligo: interplay between oxidative stress and immune system
Top Cited Papers
- 21 February 2013
- journal article
- review article
- Published by Wiley in Experimental Dermatology
- Vol. 22 (4), 245-250
- https://doi.org/10.1111/exd.12103
Abstract
Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both genetic and non-genetic factors. The precise modus operandi for vitiligo pathogenesis has remained elusive. Theories regarding loss of melanocytes are based on autoimmune, cytotoxic, oxidant-antioxidant and neural mechanisms. Reactive oxygen species (ROS) in excess have been documented in active vitiligo skin. Numerous proteins in addition to tyrosinase are affected. It is possible that oxidative stress is one among the main principal causes of vitiligo. However, there also exists ample evidence for altered immunological processes in vitiligo, particularly in chronic and progressive conditions. Both innate and adaptive arms of the immune system appear to be involved as a primary event or as a secondary promotive consequence. There is speculation on the interplay, if any, between ROS and the immune system in the pathogenesis of vitiligo. The article focuses on the scientific evidences linking oxidative stress and immune system to vitiligo pathogenesis giving credence to a convergent terminal pathway of oxidative stress-autoimmunity-mediated melanocyte loss.Keywords
This publication has 104 references indexed in Scilit:
- Association of Generalized Vitiligo with MHC Class II Loci in Patients from the Indian SubcontinentJournal of Investigative Dermatology, 2013
- Increased Tumor Necrosis Factor (TNF)-α and Its Promoter Polymorphisms Correlate with Disease Progression and Higher Susceptibility towards VitiligoPLOS ONE, 2012
- Global Activation of CD8+ Cytotoxic T Lymphocytes Correlates with an Impairment in Regulatory T Cells in Patients with Generalized VitiligoPLOS ONE, 2012
- Th17 Cells and Activated Dendritic Cells Are Increased in Vitiligo LesionsPLOS ONE, 2011
- The genetics of generalized vitiligo: autoimmune pathways and an inverse relationship with malignant melanomaGenome Medicine, 2010
- Neurogenic dysregulation, oxidative stress, autoimmunity, and melanocytorrhagy in vitiligo: can they be interconnected?Pigment Cell Research, 2007
- Association of catalase T/C exon 9 and glutathione peroxidase codon 200 polymorphisms in relation to their activities and oxidative stress with vitiligo susceptibility in Gujarat populationPigment Cell Research, 2007
- Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligoBiochemical and Biophysical Research Communications, 2004
- The Transcription Factors SOX9 and SOX10 Are Vitiligo Autoantigens in Autoimmune Polyendocrine Syndrome Type IOnline Journal of Public Health Informatics, 2001
- Aberrations in T lymphocytes and natural killer cells in vitiligo: A flow cytometric studyJournal of the American Academy of Dermatology, 1986