Emerging relevance of circadian rhythms in headaches and neuropathic pain
- 3 July 2018
- journal article
- review article
- Published by Wiley in Acta Physiologica
- Vol. 225 (1), e13161
- https://doi.org/10.1111/apha.13161
Abstract
Circadian rhythms of physiology are key to health and fitness, as dysregulation, by genetic mutations or environmental factors, increases disease risk and aggravates progression. Molecular and physiological studies have shed important light on an intrinsic clock that drives circadian rhythms and serves essential roles in metabolic homeostasis, organ physiology, and brain functions. One exciting new area in circadian research is pain, including headache and neuropathic pain for which new mechanistic insights have recently emerged. For example, cluster headache is an intermittent pain disorder with an exceedingly precise circadian timing, and preliminary evidence is emerging linking several circadian components (e.g., Clock and Nr1d1) with the disease. In this review, we first discuss the broad metabolic and physiological relevance of the circadian timing system. We then provide a detailed review of the circadian relevance in pain disease and physiology, including cluster headache, migraine, hypnic headache, and neuropathic pain. Finally, we describe potential therapeutic implications, including existing pain medicines and novel clock‐modulating compounds. The physiological basis for the circadian rhythms in pain is an exciting new area of research with profound basic and translational impact.Keywords
Funding Information
- National Institute of General Medical Sciences (GM114424)
- National Institute on Aging (AG045828)
- National Headache Foundation
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