Bridging gaps in phospholipid transport
- 31 July 2005
- journal article
- review article
- Published by Elsevier BV in Trends in Biochemical Sciences
- Vol. 30 (7), 396-404
- https://doi.org/10.1016/j.tibs.2005.05.008
Abstract
Phospholipid transport between membranes is a fundamental aspect of organelle biogenesis in eukaryotes; however, little is know about this process. A significant body of data demonstrates that newly synthesized phospholipids can move between membranes by routes that are independent of the vesicular traffic that carries membrane proteins. Evidence continues to accumulate in support of a system for phospholipid transport that occurs at zones of apposition and contact between donor membranes – the source of specific phospholipids – and acceptor membranes that are unable to synthesize the necessary lipids. Recent findings identify some of the lipids and proteins that must be present on membranes for inter-organelle phospholipid transport to occur between the endoplasmic reticulum and mitochondria or Golgi. These data suggest that protein and lipid assemblies on donors and acceptors promote membrane docking and facilitate lipid movement.Keywords
This publication has 39 references indexed in Scilit:
- Merging cultures in the study of membrane trafficNature, 2004
- Continuous Equilibration of Phosphatidylcholine and Its Precursors between Endoplasmic Reticulum and Mitochondria in YeastMolecular Biology of the Cell, 2003
- The machinery and principles of vesicle transport in the cellNature Medicine, 2002
- SEC mutants and the secretory apparatusNature Medicine, 2002
- Synthesis and Intracellular Transport of Aminoglycerophospholipids in Permeabilized Cells of the Yeast, Saccharomyces cerevisiaeJournal of Biological Chemistry, 1995
- COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeastCell, 1995
- Import of phosphatidylserine into isolated yeast mitochondriaBiochimica et Biophysica Acta (BBA) - Biomembranes, 1993
- Transport of phospholipids between subcellular membranes of wild-type yeast cells and of the phosphatidylinositol transfer protein-deficient strain Saccharomyces cerevisiae sec 14Biochimica et Biophysica Acta (BBA) - Biomembranes, 1992
- Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternaeCell, 1991
- Intracellular transport of phosphatidylcholine to the plasma membrane.The Journal of cell biology, 1985