Gastric electrical stimulation in medically refractory nausea and vomiting
- 1 January 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Gastroenterology & Hepatology
- Vol. 19 (1), 29-35
- https://doi.org/10.1097/01.meg.0000250584.15490.b4
Abstract
High-frequency gastric electrical stimulation is a new therapeutic option to improve refractory nausea and vomiting, in gastroparetic patients. Its effects on gastric emptying are, however, inconstant and limited. Therefore, we have hypothesized that high-frequency gastric electrical stimulation could be also effective in patients suffering from refractory vomiting and nausea with normal gastric emptying, and we have compared the symptomatic efficacy of high-frequency gastric electrical stimulation between patients with delayed and normal gastric emptying. Fifteen patients with chronic, severe and medically resistant nausea and vomiting were included in the study. Gastric emptying was delayed in eight patients (Group 1) and normal in seven patients (Group 2). At inclusion and at 6 months after the start of the stimulation, symptoms (nausea and vomiting, bloating, regurgitations, abdominal pain and appetite) and quality of life were prospectively evaluated using the Gastrointestinal Quality of Life Index score whereas gastric emptying was assessed by scintigraphy and/or octanoic acid breath test. Age, sex, symptoms and quality of life were not different at baseline between the two groups. At 6 months, Gastrointestinal Quality of Life Index and nausea/vomiting scores had significantly improved in both groups. Other symptoms (bloating, regurgitations, abdominal pain and appetite) had improved at 6 months in Group 1 but not in Group 2. Six months after the start of stimulation, gastric emptying was normal in 4/8 Group 1 patients and 5/7 Group 2 patients but was not significantly different from that calculated before the implantation of the stimulator. Our results suggest that high-frequency gastric electrical stimulation could be an effective therapy for treating chronic, severe vomiting and nausea whether gastric emptying is delayed or not.Keywords
This publication has 17 references indexed in Scilit:
- Is gastric electrical stimulation superior to standard pharmacologic therapy in improving GI symptoms, healthcare resources, and long‐term health care benefits?Neurogastroenterology & Motility, 2005
- Clinical response to gastric electrical stimulation in patients with postsurgical gastroparesisClinical Gastroenterology and Hepatology, 2004
- American Gastroenterological Association technical review on the diagnosis and treatment of gastroparesisGastroenterology, 2004
- Treatment of Diabetic Gastroparesis by High-Frequency Gastric Electrical StimulationDiabetes Care, 2004
- Effect of high‐frequency gastric electrical stimulation on gastric myoelectric activity in gastroparetic patientsNeurogastroenterology & Motility, 2004
- Further experience with gastric stimulation to treat drug refractory gastroparesisThe American Journal of Surgery, 2003
- Gastric electrical stimulation for medically refractory gastroparesisGastroenterology, 2003
- Gastric electrical stimulation for gastroparesis improves nutritional parameters at short, intermediate, and long‐term follow‐upJournal of Parenteral and Enteral Nutrition, 2003
- Gastric Electrical Stimulation in Intractable Symptomatic GastroparesisDigestion, 2002
- Gastrointestinal Quality of Life Index: Development, validation and application of a new instrumentBritish Journal of Surgery, 1995