Correlation of Diffusion and Perfusion MRI With Ki-67 in High-Grade Meningiomas
- 1 December 2010
- journal article
- Published by American Roentgen Ray Society in American Journal of Roentgenology
- Vol. 195 (6), 1391-1395
- https://doi.org/10.2214/ajr.10.4531
Abstract
OBJECTIVE. Atypical and anaplastic meningiomas have a greater likelihood of recurrence than benign meningiomas. The risk for recurrence is often estimated using the Ki-67 labeling index. The purpose of this study was to determine the correlation between Ki-67 and regional cerebral blood volume (rCBV) and between Ki-67 and apparent diffusion coefficient (ADC) in atypical and anaplastic meningiomas.MATERIALS AND METHODS. A retrospective review of the advanced imaging and immunohistochemical characteristics of atypical and anaplastic meningiomas was performed. The relative minimum ADC, relative maximum rCBV, and specimen Ki-67 index were measured. Pearson's correlation was used to compare these parameters.RESULTS. There were 23 cases with available ADC maps and 20 cases with available rCBV maps. The average Ki-67 among the cases with ADC maps and rCBV maps was 17.6% (range, 5–38%) and 16.7% (range, 3–38%), respectively. The mean minimum ADC ratio was 0.91 (SD, 0.26) and the mean maximum rCBV ratio was 22.5 (...This publication has 24 references indexed in Scilit:
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