Estimating the fraction reabsorbed in drugs undergoing enterohepatic circulation
- 1 August 1982
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 10 (4), 455-461
- https://doi.org/10.1007/bf01065175
Abstract
A simple method of estimating the extent of biliary recycling using blood level and cumulative biliary excretion data from control and bile duct-cannulated animals is described. The method was tested in rats following an intravenous dose of [14C] temazepam. It was shown that 62% of the drug excreted in the bile of control rats was reabsorbed during each enterohepatic cycle, contributing to the secondary peak blood concentrations and a prolonged elimination halflife.This publication has 9 references indexed in Scilit:
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