Early Detection of Kawasaki Disease in Infants
Open Access
- 1 January 2015
- journal article
- Published by The Korean Society of Cardiology in Korean Circulation Journal
- Vol. 45 (6), 510-515
- https://doi.org/10.4070/kcj.2015.45.6.510
Abstract
This study aimed to investigate the clinical characteristics of infantile Kawasaki disease (KD), and to evaluate early diagnostic features of KD in febrile infants. We retrospectively reviewed the medical records of 64 KD patients from January 2010 to October 2014. There was an analysis of the clinical, laboratory data of the infants versus children groups. Furthermore, the clinical and laboratory data of infantile KD patients were compared with 16 infants who were admitted for other acute febrile diseases. A total of 64 patients with KD were identified; 20 (31.3%) were infants; 44 (68.8%) were >1 year old children. Incomplete KD was much more common in infants (n=13, 65.0%) than in children group (n=14, 31.8%) (p=0.013). The infants were characterized by significantly higher rates of inflammatory changes at the Bacille Calmett-Guérin (BCG) inoculation site (p<0.001), but lower rates of changes in the extremities (p=0.029) and cervical lymphadenopathy (p=0.006). The serum levels of platelet after 1 week (p=0.005), C-reactive protein (p=0.038), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (p=0.026) were all significantly higher in the infants group. Comparing the infants with KD versus the other acute febrile diseases, there were significantly higher serum levels of erythrocyte sedimentation rate (p=0.002), C-reactive protein (p=0.046) and NT-proBNP (p=0.001) for the infants with KD group. BCGitis and higher levels of NT-proBNP can be helpful for early diagnosis of the incomplete KD in infants, and may be a good predictor of KD in acute febrile infants, when combined with other acute phase reactants.Keywords
This publication has 23 references indexed in Scilit:
- Diagnosis of Incomplete Kawasaki Disease in Infants Based on an Inflammation at the Bacille Calmette-Guérin Inoculation SiteKorean Circulation Journal, 2012
- Kawasaki Disease Patients With Redness or Crust Formation at the Bacille Calmette-Guérin Inoculation SiteThe Pediatric Infectious Disease Journal, 2010
- Comparative study of complete versus incomplete Kawasaki disease in 59 pediatric patientsJoint Bone Spine, 2009
- Kawasaki Disease at the Extremes of the Age SpectrumPublished by American Academy of Pediatrics (AAP) ,2009
- Letters to the EditorJournal of Paediatrics and Child Health, 2008
- Characteristics of Kawasaki Disease in Infants Younger than Six Months of AgeThe Pediatric Infectious Disease Journal, 2006
- BCG reactivation: a useful diagnostic tool even for incomplete Kawasaki diseaseArchives of Disease in Childhood, 2005
- Diagnosis, Treatment, and Long-Term Management of Kawasaki DiseaseCirculation, 2004
- The Amino-Terminal Portion of Pro-Brain Natriuretic Peptide (Pro-BNP) Circulates in Human PlasmaBiochemical and Biophysical Research Communications, 1995
- Diagnosis and therapy of Kawasaki disease in children.Circulation, 1993