Hematological manifestations of copper deficiency: a retrospective review
- 13 February 2008
- journal article
- review article
- Published by Wiley in European Journal of Haematology
- Vol. 80 (6), 523-531
- https://doi.org/10.1111/j.1600-0609.2008.01050.x
Abstract
Copper deficiency is an established cause of hematological abnormalities but is frequently misdiagnosed. Copper deficiency can present as a combination of hematological and neurological abnormalities and it may masquerade as a myelodysplastic syndrome. We reviewed the records of patients with hypocupremia and hematologic abnormalities identified between 1970 and 2005. Patients with hypocupremia unrelated to copper deficiency (e.g. Wilson's disease) were excluded. Forty patients with copper deficiency and hematological abnormalities were identified. Ten patients (25%) had undergone bariatric (weight reduction) surgery and an additional 14 patients (35%) had undergone surgery on the gastrointestinal tract, most commonly gastric resection. In 12 cases, no cause for copper deficiency was identified. Anemia and neutropenia were the most common hematologic abnormalities identified and the majority of the patients also had neurologic findings, most commonly due to myeloneuropathy. Abnormalities observed on bone marrow examination including vacuoles in myeloid precursors, iron-containing plasma cells, a decrease in granulocyte precursors and ring sideroblasts may be valuable clues to the diagnosis. Copper deficiency is an uncommon but very treatable cause of hematologic abnormalities.Keywords
This publication has 67 references indexed in Scilit:
- Neutropenia Caused by Copper Deficiency: Possible Mechanisms of ActionNutrition Reviews, 2009
- Copper deficiency causes reversible myelodysplasiaAmerican Journal of Hematology, 2007
- Hohenheim Consensus Workshop: CopperEuropean Journal of Clinical Nutrition, 2002
- Storage of Iron in Bone Marrow Plasma CellsActa Haematologica, 1999
- Copper Deficiency With Pancytopenia During Total Parenteral NutritionJournal of Parenteral and Enteral Nutrition, 1994
- Anemia and Neutropenia Due to Copper Deficiency in Enteral NutritionJournal of Parenteral and Enteral Nutrition, 1994
- Anti-neutrophil antibodies in patients with nutritional copper deficiencyEuropean Journal of Pediatrics, 1991
- Neutropenia Due to Copper Deficiency in Total Parenteral NutritionJournal of Parenteral and Enteral Nutrition, 1986
- Severe Pancytopenia due to Copper DeficiencyActa Haematologica, 1986
- Copper Deficiency in Infants with Active Celiac DiseaseJournal of Pediatric Gastroenterology and Nutrition, 1985